Potassium Carbonate → HCID 19525517、化合物

温度

70 °C

To a 4 mL vial equipped with a magnetic stir bar were added 4-bromo-3,5-dimethyl-1H-pyrazole (50 mg, 0.286 mmol), 2-bromo-N-isopropylacetamide (51.4 mg, 0.286 mmol), K2CO3 (118 mg, 0.857 mmol), and acetonitrile (2 mL). The contents of the vial were stirred to give a white suspension. The vial was heated in a sand bath to 70° C. for 24 hours. The reaction mixture was subsequently partitioned between water (10 mL) and ethyl acetate (15 mL). The layers were separated, and the aqueous layer was back-extracted with ethyl acetate (15 mL). The combined organic layers were concentrated to give the title compound as a white solid, which was used without further purification (80 mg).

1. customTo a 4 mL vial equipped with a magnetic stir bar
2. customto give a white suspension
3. customThe reaction mixture was subsequently partitioned between water (10 mL) and ethyl acetate (15 mL)
4. customThe layers were separated
5. extractionthe aqueous layer was back-extracted with ethyl acetate (15 mL)
6. concentrationThe combined organic layers were concentrated

ORDレコード

ord-9b7a6a77cab942a590f5687551911879

出典データセット

uspto-grants-2016_09

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US09434743B2