HCID 70202469、化合物 → rac-tert-butyl N-[(3R,4S)-4-methylpyrrolidin-3-yl]carbamate
反応式
C([N:8]1[CH2:12][C@@H:11]([CH3:13])[C@H:10]([NH:14][C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:9]1)C1C=CC=CC=1.[H][H]>C(O)C.[Pd]>[C:18]([O:17][C:15]([NH:14][C@H:10]1[C@H:11]([CH3:13])[CH2:12][NH:8][CH2:9]1)=[O:16])([CH3:21])([CH3:19])[CH3:20]参加物
5
実験手順
A suspension of 1-benzyl-trans-3-t-butoxycarbonylamino-4-methylpyrrolidine (4.8 g) and 10% palladium-on-charcoal (1.8 g) in ethanol (40 ml) was shaken with hydrogen were absorbed under elevated pressure (100 kg/cm2) at 50°-70° C. for 6.5 hours. The catalyst was removed by filtration and the filtrate was evaporated to give the title compound (3.09 g) as brown oil. This oil was gradually solidified at room temperature.
後処理
- customwere absorbed under elevated pressure (100 kg/cm2) at 50°-70° C. for 6.5 hours
- customThe catalyst was removed by filtration
- customthe filtrate was evaporated
出典と根拠
- ORDレコード
- ord-cba856acedb249e185beebb58b31f2d8
- 出典データセット
- uspto-grants-1988_06
- 特許番号
- US04753953
反応ノート
読み込み中…