3-Chloroaniline → HCID 11629788、化合物
反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][CH:8]=1)[NH2:5].C(=O)([O-])[O-].[K+].[K+].[CH3:15][O:16][C:17](=[O:20])[CH2:18]Br.CCOC(C)=O>CN(C=O)C>[Cl:1][C:2]1[CH:3]=[C:4]([NH:5][CH2:18][C:17]([O:16][CH3:15])=[O:20])[CH:6]=[CH:7][CH:8]=1参加物
6
反応条件
- 温度
- 60 °C
実験手順
To a solution of 3-chloroaniline and potassium carbonate (3 equiv.) in DMF is added methylbromoacetate (1.1 equiv.), and the reaction is stirred at 60° C. After complete reaction, the solution is poured into EtOAc and washed with water, sat. aq. NaHCO3 soln., and brine. The solution is dried (Na2SO4), filtered, and concentrated in vacuo. The resulting material is purified by silica gel chromatography to provide the titled compound.
後処理
- customAfter complete reaction
- washwashed with water, sat. aq. NaHCO3 soln
- dry with materialThe solution is dried (Na2SO4)
- filtrationfiltered
- concentrationconcentrated in vacuo
- customThe resulting material is purified by silica gel chromatography
出典と根拠
- ORDレコード
- ord-a725d08ce0c04d57bccbf93f0443fb94
- 出典データセット
- uspto-grants-1999_07
- 特許番号
- US05919785
反応ノート
読み込み中…