Trifluoroacetic acid → 6-Bromo-2-(4-piperidinyl)-1,8-naphthyridine
反応式
C([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[CH:23]=[CH:22][C:21]3[C:16](=[N:17][CH:18]=[C:19]([Br:24])[CH:20]=3)[N:15]=2)[CH2:10][CH2:9]1)(OC(C)(C)C)=O.C(O)(C(F)(F)F)=O>C(Cl)Cl>[Br:24][C:19]1[CH:20]=[C:21]2[C:16](=[N:17][CH:18]=1)[N:15]=[C:14]([CH:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)[CH:23]=[CH:22]2参加物
4
実験手順
A solution of bromide 3-4 (3.5 g, 8.92 mmol), CH2Cl2 (20 ml) and TFA (10 ml) was stirred for 1.0 h. The reaction was concentrated and then azeotroped with toluene. The residue was dissolved in 1N NaOH and then extracted with CHCl3. The CHCl3 portion was washed with brine, dried (MgSO4) and concentrated providing amine 3-5 as a brown solid.
後処理
- concentrationThe reaction was concentrated
- customazeotroped with toluene
- dissolutionThe residue was dissolved in 1N NaOH
- extractionextracted with CHCl3
- washThe CHCl3 portion was washed with brine
- dry with materialdried (MgSO4)
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-c6d2dd03aec94ef382b84d7c15b896a8
- 出典データセット
- uspto-grants-1999_07
- 特許番号
- US05919792
反応ノート
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