1-Benzyloxy-4-(2-methoxyethoxy)benzene → 4-(2-Methoxyethoxy)phenol

HRID 580974ノート

反応式

HRID 580974 の反応式
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH2:16][CH2:17][O:18][CH3:19])=[CH:11][CH:10]=1)C1C=CC=CC=1>[Pd].C(O)C>[CH3:19][O:18][CH2:17][CH2:16][O:15][C:12]1[CH:13]=[CH:14][C:9]([OH:8])=[CH:10][CH:11]=1

参加物

4

反応物 1

HCID 133135851-Benzyloxy-4-(2-methoxyethoxy)benzene

生成物 1

HCID 133135614-(2-Methoxyethoxy)phenol収率 80.8%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A mixture of 1-(benzyloxy)-4-(2-methoxyethoxy)benzene (180 g), ethanol (2000 ml) and palladium on carbon catalyst (20 g) was stirred under an atmosphere of hydrogen, at room temperature and atmospheric pressure. After the theoretical quantity of hydrogen had been consumed, the reaction mixture was filtered. The filtrate was evaporated to give a solid which was crystallised from a mixture of ethyl acetate and n-hexane to give 4-(2-methoxyethoxy)phenol as a solid (94.7 g) m.p. 97.9° C.; microanalysis, found: C, 64.3%; H, 7.4%; C9H12O3 requires: C, 64.3%; H, 7.2%; NMR: 3.35(3H,s), 3.6(2H,m), 3.95(2H,m), 6.7(4H,m) and 8.9(1H,s); m/z 169(M+H).

後処理

  1. customAfter the theoretical quantity of hydrogen had been consumed
  2. filtrationthe reaction mixture was filtered
  3. customThe filtrate was evaporated
  4. customto give a solid which
  5. customwas crystallised from a mixture of ethyl acetate and n-hexane

出典と根拠

ORDレコード
ord-769281acd38042f988026185e71a313c
出典データセット
uspto-grants-1999_07
特許番号
US05919793

反応ノート

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