Butylamine → 2-(4-Iodophenyl)acetamide

HRID 580998ノート

反応式

HRID 580998 の反応式
C([NH2:5])CCC.[I:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][C:14](Cl)=[O:15])=[CH:9][CH:8]=1>CCOCC>[I:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][C:14]([NH2:5])=[O:15])=[CH:9][CH:8]=1

参加物

4

反応物 2

HCID 8007ButylamineHCID 13340573HCID 13340573、化合物

生成物 1

HCID 130308042-(4-Iodophenyl)acetamide

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

1-Butylamine (1.83 g) was added to a solution of 4-iodophenylacetyl chloride (2.80 g) in ether (25 ml), and the reaction mixture was stirred at ambient temperature for 5 minutes. The reaction mixture was then partitioned between water (30 ml) and ethyl acetate (50 ml). The organic layer was washed with 2M aqueous hydrochloric acid (25 ml), water (30 ml), brine (25 ml), dried (MgSO4), and evaporated to give N-1-butyl, (4-iodophenyl)acetamide, as a colourless crystalline solid, (2.9 g), mp.: 100-102° C., NMR: 0.82-0.88(3H,t), 1.18-1.43(4H,m), 3.00-3.06(2H,q), 3.35(2H,s), 7.03-7.67(4H,AB), 7.97(H,bt); m/z 318 (M+H).

後処理

  1. customThe reaction mixture was then partitioned between water (30 ml) and ethyl acetate (50 ml)
  2. washThe organic layer was washed with 2M aqueous hydrochloric acid (25 ml), water (30 ml), brine (25 ml)
  3. dry with materialdried (MgSO4)
  4. customevaporated

出典と根拠

ORDレコード
ord-31e4fb2631ad4e01a070e77db430aa63
出典データセット
uspto-grants-1999_07
特許番号
US05919793

反応ノート

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