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Sodium Bicarbonate → 3-fluoro-4-(6-(trifluoromethyl)-1H-indazol-4-yl)benzenesulfonamide

HRID 58100
ノート
印刷プレビュー

反応式

HRID 58100 の反応式
CC1(C)C(C)(C)OB([C:9]2[CH:17]=[C:16]([C:18]([F:21])([F:20])[F:19])[CH:15]=[C:14]3[C:10]=2[CH:11]=[N:12][NH:13]3)O1.Br[C:24]1[CH:29]=[CH:28][C:27]([S:30]([NH2:33])(=[O:32])=[O:31])=[CH:26][C:25]=1[F:34].[C:35](=[O:38])(O)[O-:36].[Na+]>C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2].O1CCOCC1>[C:35]([OH:36])([C:18]([F:21])([F:20])[F:19])=[O:38].[F:34][C:25]1[CH:26]=[C:27]([S:30]([NH2:33])(=[O:31])=[O:32])[CH:28]=[CH:29][C:24]=1[C:9]1[CH:17]=[C:16]([C:18]([F:19])([F:20])[F:21])[CH:15]=[C:14]2[C:10]=1[CH:11]=[N:12][NH:13]2
参加物反応条件実験手順後処理出典と根拠反応ノート

参加物

7

反応物 3

HCID 516892Sodium BicarbonateHCID 27784044-Bromo-3-fluorobenzene-1-sulfonamideHCID 897828064-(Tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trifluoromethyl)-1H-indazole

生成物 2

HCID 6422Trifluoroacetic acidHCID 897828143-fluoro-4-(6-(trifluoromethyl)-1H-indazol-4-yl)benzenesulfonamide収率 59.6%

試薬・触媒・溶媒 2

HCID 44119782Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+)触媒
HCID 312751,4-Dioxane溶媒

反応条件

温度
140 °C

実験手順

To a 5 mL vial equipped with a magnetic stir bar were added 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trifluoromethyl)-1H-indazole (40 mg, 0.128 mmol), 4-bromo-3-fluorobenzenesulfonamide (39.1 mg, 0.154 mmol), aqueous saturated sodium bicarbonate (0.274 mL, 0.513 mmol), PdCl2(dppf) (9.38 mg, 0.013 mmol), and dioxane (2 mL) to give an orange suspension. The vial was sealed and then heated in a microwave reactor at 140° C. for 30 minutes. The reaction mixture was subsequently filtered and the product was purified by preparative HPLC, eluting with a gradient of 35-60% ACN (containing 0.035% TFA) in H2O (containing 0.05% TFA). The pure fractions were lyophilized to give a TFA salt of the title compound as a white solid (13.7 mg, 22.6%). 1H NMR (400 MHz, DMSO-d6) δ ppm 7.50 (s, 2H), 7.53 (s, 1H), 7.75-7.80 (m, 1H), 7.92-7.94 (m, 1H), 8.02 (s, 1H), 8.06 (dt, J=8.02, 1.29 Hz, 1H), 8.21 (t, J=1.64 Hz, 1H), 8.40 (s, 1H); ESI-MS m/z [M+H]+ calc'd for C14H9F4N3O2S, 360.0. found 360.1.

後処理

  1. customTo a 5 mL vial equipped with a magnetic stir bar
  2. customto give an orange suspension
  3. customThe vial was sealed
  4. filtrationThe reaction mixture was subsequently filtered
  5. customthe product was purified by preparative HPLC
  6. washeluting with a gradient of 35-60% ACN (containing 0.035% TFA) in H2O (containing 0.05% TFA)

出典と根拠

ORDレコード
ord-1af81cde047c419ca4041ba7ffe19fbe
出典データセット
uspto-grants-2016_09
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US09434743B2

反応ノート

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