Benzyl Alcohol → HCID 18705291、化合物

HRID 581043

反応式

HRID 581043 の反応式
[O:1]=[C:2]1[O:6][CH:5]([C:7]([OH:9])=[O:8])[CH:4]([C:10]([OH:12])=[O:11])[CH2:3]1.C1(N=C=NC2CCCCC2)CCCCC1.[CH2:28](O)[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1>CC(C)=O>[CH2:28]([O:8][C:7]([CH:5]1[CH:4]([C:10]([OH:12])=[O:11])[CH2:3][C:2](=[O:1])[O:6]1)=[O:9])[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1

参加物

5

反応物 3

HCID 244Benzyl AlcoholHCID 10868DicyclohexylcarbodiimideHCID 98259Tetrahydro-5-oxofuran-2,3-dicarboxylic acid

生成物 1

HCID 18705291HCID 18705291、化合物

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

5.3 g of (2RS,3SR)-5-oxotetrahydrofuran-2,3-dicarboxylic acid was dissolved in 90 ml of acetone, and 6.6 g of N,N'-dicyclohexylcarbodiimide was added thereto, followed by stirring at room temperature for 2.5 hours. 3.3 ml of benzyl alcohol was added to the reaction solution, followed by stirring at the same temperature for 2 days. Insoluble matters were filtered off, and then the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate=4/1+chloroform/methanol=50/1) to obtain 6.55 g of the above-identified compound as a yellow solid.

後処理

  1. stirringby stirring at the same temperature for 2 days
  2. filtrationInsoluble matters were filtered off
  3. concentrationthe filtrate was concentrated under reduced pressure
  4. customThe residue was purified by silica gel column chromatography (hexane/ethyl acetate=4/1+chloroform/methanol=50/1)

出典と根拠

ORDレコード
ord-ec1dfca3ad4d4dd08be4353809871e80
出典データセット
uspto-grants-1999_07
特許番号
US05919786

関連ノート

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