Hydrochloric Acid → 2-Amino-5-methoxybenzene-1-thiol

HRID 581047

反応式

HRID 581047 の反応式
NC1[S:3][C:4]2[CH:10]=[C:9]([O:11][CH3:12])[CH:8]=[CH:7][C:5]=2[N:6]=1.[OH-].[K+].Cl>O>[NH2:6][C:5]1[CH:7]=[CH:8][C:9]([O:11][CH3:12])=[CH:10][C:4]=1[SH:3]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 156302-Amino-6-methoxybenzothiazole

生成物 1

HCID 2355092-Amino-5-methoxybenzene-1-thiol

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

34.3 g (0.19 mol) of 2-amino-6-methoxy-benzothiazole and 140 g (2.5 mol) of 85% potassium hydroxide are refluxed in 350 ml of water for 5 hours. Then the mixture is cooled and neutralised with 200 ml of concentrated hydrochloric acid. The mixture is stirred for a further 30 minutes, the precipitate formed is suction filtered, washed with water and dried in vacuo. Yield: 24.0 g (81.4% of theory). The following is obtained analogously to Example B:

後処理

  1. temperatureThen the mixture is cooled
  2. customthe precipitate formed
  3. filtrationfiltered
  4. washwashed with water
  5. customdried in vacuo
  6. customThe following is obtained analogously to Example B

出典と根拠

ORDレコード
ord-1b43938fb5074402905e3d3e73f51a4f
出典データセット
uspto-grants-1999_07
特許番号
US05919807

関連ノート

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