Thionyl Chloride → 4-(4-Methoxyphenyl)butanoyl chloride

HRID 581110

反応式

HRID 581110 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][CH2:11][C:12]([OH:14])=O)=[CH:5][CH:4]=1.S(Cl)([Cl:17])=O>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][CH2:11][C:12]([Cl:17])=[O:14])=[CH:5][CH:4]=1

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 782804-(4-Methoxyphenyl)butyric acid

生成物 1

HCID 27596424-(4-Methoxyphenyl)butanoyl chloride

実験手順

4-(4-Methoxyphenyl)butyric acid (2.0 g, 10.3 mmol) was treated with thionyl chloride (20 mL). The reaction was stirred at rt for 3 h, heated at 65° C. overnight and then concentrated under reduced pressure to give 4-(4-methoxyphenyl)butyryl chloride (2.3 g) as a yellow oil which was used without farther purification. IR (NaCl): 1795, 1510, 1244 cm-1.

後処理

  1. temperatureheated at 65° C. overnight
  2. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-173a82d0122c4697bcecfa067c48791d
出典データセット
uspto-grants-1999_07
特許番号
US05919768

関連ノート

読み込み中…