Benzene, 2-fluoro-4-methyl-1-nitro- → [2-(3-Fluoro-4-nitro-phenyl)-vinyl]-dimethyl-amine

HRID 58170

反応式

HRID 58170 の反応式
[F:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].CO[CH:14](OC)[N:15]([CH3:17])[CH3:16]>CN(C=O)C>[F:1][C:2]1[CH:7]=[C:6]([CH:8]=[CH:14][N:15]([CH3:17])[CH3:16])[CH:5]=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10]

参加物

4

反応物 2

HCID 67966Benzene, 2-fluoro-4-methyl-1-nitro-HCID 78373Dimethylformamide dimethyl acetal

生成物 1

HCID 91252016[2-(3-Fluoro-4-nitro-phenyl)-vinyl]-dimethyl-amine収率 63%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
125 °C

実験手順

A mixture of 2-fluoro-4-methyl-1-nitro-benzene (3 g, 19.3 mmol), N,N-dimethylformamide dimethylacetal (10 mL) and 3 mL of DMF (30 mL) was heated at 125° C. for 1 hour. The mixture was cooled and concentrated under reduced pressure to give a purple solid. Trituration with hexanes gave the pure title product (2.5 g, yield: 63%). MS (ESI): 211 [M+H]+.

後処理

  1. temperatureThe mixture was cooled
  2. concentrationconcentrated under reduced pressure
  3. customto give a purple solid

出典と根拠

ORDレコード
ord-817877ea94764f208294308ee7121a8b
出典データセット
uspto-grants-2016_09
特許番号
US09434697B2

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