Pyridine → HCID 86754218、化合物

反応式

[CH:1]1([CH2:6][OH:7])[CH2:5][CH:4]=[CH:3][CH2:2]1.[C:8]1(C)[CH:13]=[CH:12][C:11]([S:14](Cl)(=[O:16])=[O:15])=[CH:10][CH:9]=1.N1C=CC=C[CH:20]=1>>[C:10]1([CH3:20])[C:11]([S:14]([O:7][CH2:6][CH:1]2[CH2:5][CH:4]=[CH:3][CH2:2]2)(=[O:15])=[O:16])=[CH:12][CH:13]=[CH:8][CH:9]=1

参加物

反応物 3

HCID 1049Pyridine

HCID 73974-Toluenesulfonyl chloride

HCID 1514122Cyclopent-3-en-1-ylmethanol

生成物 1

HCID 86754218HCID 86754218、化合物収率 83.2%

実験手順

A mixture of (cyclopent-3-en-1-yl)methanol (1.96 g, 20 mmol) and para-toluenesulfonylchloride (3.81 g, 20 mmol) were stirred at room temperature for 2 hrs in pyridine (30 ml). After the concentration of pyridine, the reaction residues were extracted with dichloromethane, washed 1N HCl, dried with MgSO4, concentrated and separated by the column chromatography to give the desirable product (4.20 g).

後処理

extractionAfter the concentration of pyridine, the reaction residues were extracted with dichloromethane
washwashed 1N HCl
dry with materialdried with MgSO4
concentrationconcentrated
customseparated by the column chromatography

出典と根拠

ORDレコード: ord-82c9268c62c04cfea2182649ff42a46c
出典データセット: uspto-grants-1999_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05922727

反応ノート

読み込み中…

参加物