5-Isopropyl-6-(3,5-dimethylphenyl)thio-2,4-pyrimidinedione → 1-{[3,4-Di(hydroxymethyl)cyclopent-1-en-1-yl]methyl}-5-isopropyl-6-(3,5-dimethylphenylthio)-2,4-pyrimidinedione

HRID 581874

反応式

HRID 581874 の反応式
[CH:1]([C:4]1[C:5](=[O:20])[NH:6][C:7](=[O:19])[NH:8][C:9]=1[S:10][C:11]1[CH:16]=[C:15]([CH3:17])[CH:14]=[C:13]([CH3:18])[CH:12]=1)([CH3:3])[CH3:2].[Si]([O:28][CH2:29][CH:30]1[CH:34]([CH2:35][O:36][Si](C(C)(C)C)(C)C)[CH2:33][C:32]([CH2:44]Br)=[CH:31]1)(C(C)(C)C)(C)C>>[OH:28][CH2:29][CH:30]1[CH:34]([CH2:35][OH:36])[CH2:33][C:32]([CH2:44][N:8]2[C:9]([S:10][C:11]3[CH:12]=[C:13]([CH3:18])[CH:14]=[C:15]([CH3:17])[CH:16]=3)=[C:4]([CH:1]([CH3:3])[CH3:2])[C:5](=[O:20])[NH:6][C:7]2=[O:19])=[CH:31]1

参加物

3

反応物 2

HCID 104937275-Isopropyl-6-(3,5-dimethylphenyl)thio-2,4-pyrimidinedioneHCID 54350482[3,4-Di(t-butyldimethylsilyloxymethyl)cyclopent-1-en-1-yl]methyl bromide

生成物 1

HCID 699775951-{[3,4-Di(hydroxymethyl)cyclopent-1-en-1-yl]methyl}-5-isopropyl-6-(3,5-dimethylphenylthio)-2,4-pyrimidinedione収率 17.9%

実験手順

5-Isopropyl-6-(3,5-dimethylphenylthio)-2,4-pyrimidinedione and [3,4-di(t-butyldimethylsilyloxymethyl)cyclopent-1-en-1-yl]methyl bromide were reacted by the same method with example 28 to obtain the titled compound (51 mg).

出典と根拠

ORDレコード
ord-1a1620b703ea43c086cba115d9b3d26b
出典データセット
uspto-grants-1999_07
特許番号
US05922727

関連ノート

読み込み中…