2-(Tributylstannyl)-1,3-thiazole → 5-Acetyl-1-(3-(2-thiazolyl)phenyl)benzimidazole

To a solution of (33) (3.6 g, 9.7 mmol) in dry THF (20 ml) was added 5-acetyl-1-(3-bromophenyl)benzimidazole (1.5 g, 4.8 mmol) and (PPh3)2PdCl2 (340 mg, 0.48 mmol) under argon. The reaction mixture was stirred at 80° C. for 24 hr in a 50 ml sealed tube. After cooling the mixture was concentrated, triturated with water (100 ml) and extracted with CH2Cl2 (200 ml×3). The extract was washed with brine, dried and concentrated under reduced pressure. The residue was washed with ether to afford crystaline (34) (1.5 g, 89%).

1. customsealed tube
2. temperatureAfter cooling the mixture
3. concentrationwas concentrated
4. customtriturated with water (100 ml)
5. extractionextracted with CH2Cl2 (200 ml×3)
6. washThe extract was washed with brine
7. customdried
8. concentrationconcentrated under reduced pressure
9. washThe residue was washed with ether

ORDレコード

ord-18d5d5eb6be0453a85f7fbb570da8450

出典データセット

uspto-grants-1999_07

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US05922724