HCID 53660198、化合物 → 1H-Indole, 5-broMo-6-Methoxy-

HRID 581990ノート

反応式

HRID 581990 の反応式
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[O:11][CH3:12])[N:7](S(C)(=O)=O)[CH:6]=[CH:5]2>[OH-].[Na+].C(O)C>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[O:11][CH3:12])[NH:7][CH:6]=[CH:5]2

参加物

4

反応物 1

HCID 53660198HCID 53660198、化合物

生成物 1

HCID 534184371H-Indole, 5-broMo-6-Methoxy-収率 99.3%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 14798Sodium Hydroxide溶媒

実験手順

The 1-methylsulphonylindole (D19, 21.2 g, 69.7 mmol) was heated under reflux in a mixture of 10% aqueous sodium hydroxide solution (170 ml) and ethanol (1.0 L) for 1.5 h. The mixture was evaporated almost to dryness, and the residue was dissolved in ethyl acetate and washed with water. The organic phase was dried and evaporated to give the title compound (15.65 g, 99%), mp 110-111° C.

後処理

  1. customThe mixture was evaporated almost to dryness
  2. dissolutionthe residue was dissolved in ethyl acetate
  3. washwashed with water
  4. customThe organic phase was dried
  5. customevaporated

出典と根拠

ORDレコード
ord-30c79622ed794261a725e7ef08475ba7
出典データセット
uspto-grants-1999_07
特許番号
US05922733

反応ノート

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