関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrogen Bromide | HCID 260 | — |
| 反応物 | Hydrogen iodide | HCID 24841 | — |
| 反応物 | 1-Piperidinecarboxylic acid, 4-(1H-benzimidazol-2-ylamino)-, ethyl ester | HCID 3018455 | — |
| 生成物 | (1H-benzimidazol-2-yl)(piperidin-4-yl)amine hydriodic acid | HCID 86754231 | — |
反応手順
Combine (1H-benzimidazol-2-yl)(1-ethoxycarbonylpiperidin-4-yl)amine (4.63 g, 16 mmol) and 48% hydrobromic acid (75 mL). Heat to reflux. After 1.5 hours, cool and evaporate in vacuo to give a solid. Add 47% hydriodic acid (30 mL) and heat at about 90° C. After 30 minutes cool to obtain a solid. Collect the solid by filtration, rinse with ethanol and diethyl ether, and dry to give the title compound: mp; >290° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05922737 |
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| 出典データセット | uspto-grants-1999_07 |
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| ORD ID | ord-aee88f53eb1d437ca8bfa1a5fbb4d85e |
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| 出典メモ | uspto-grants-1999_07 |
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