反应详情

温度

90 °C

Combine (1H-benzimidazol-2-yl)(1-ethoxycarbonylpiperidin-4-yl)amine (4.63 g, 16 mmol) and 48% hydrobromic acid (75 mL). Heat to reflux. After 1.5 hours, cool and evaporate in vacuo to give a solid. Add 47% hydriodic acid (30 mL) and heat at about 90° C. After 30 minutes cool to obtain a solid. Collect the solid by filtration, rinse with ethanol and diethyl ether, and dry to give the title compound: mp; >290° C.

1. temperatureHeat to reflux
2. temperaturecool
3. customevaporate in vacuo
4. customto give a solid
5. temperatureAfter 30 minutes cool
6. customto obtain a solid
7. customCollect the solid
8. filtrationby filtration
9. washrinse with ethanol and diethyl ether
10. customdry