Isopropanol → HCID 22009201、化合物

HRID 582071

反応式

HRID 582071 の反応式
[OH:1][CH2:2][C:3]1[O:7][C:6]([CH2:8][N:9]2[C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=3[N:11]=[C:10]2[NH:18][CH:19]2[CH2:24][CH2:23][N:22](C(OCC)=O)[CH2:21][CH2:20]2)=[CH:5][CH:4]=1.[OH-].[K+].C(O)(C)C>O>[OH:1][CH2:2][C:3]1[O:7][C:6]([CH2:8][N:9]2[C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=3[N:11]=[C:10]2[NH:18][CH:19]2[CH2:20][CH2:21][NH:22][CH2:23][CH2:24]2)=[CH:5][CH:4]=1

参加物

5

反応物 3

HCID 3776IsopropanolHCID 14797Potassium HydroxideHCID 22009043(1-(5-hydroxymethylfur-2-ylmethyl)-1H-benzimidazol-2-yl)(1-ethoxycarbonylpiperidin-4-yl)amine

生成物 1

HCID 22009201HCID 22009201、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Combine (1-(5-hydroxymethylfur-2-ylmethyl)-1H-benzimidazol-2-yl)(1-ethoxycarbonylpiperidin-4-yl)amine (1 mmol), potassium hydroxide (1.2 mmcl), and isopropanol (20 mL). Heat to reflux. After 18 hours, evaporate intcacuo to give a residue. Combine the resczue and water. Extract with dichloromethane. Dry the organic layer over MgSO4, filter, and evaporate in vacuo to give the title compound.

後処理

  1. temperatureHeat to reflux
  2. customevaporate intcacuo
  3. customto give a residue
  4. extractionExtract with dichloromethane
  5. dry with materialDry the organic layer over MgSO4
  6. filtrationfilter
  7. customevaporate in vacuo

出典と根拠

ORDレコード
ord-d21f8daaa0be4e20a557898196d14481
出典データセット
uspto-grants-1999_07
特許番号
US05922737

関連ノート

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