Sulfuric Acid → 2-Methoxyaniline

HRID 582251

反応式

HRID 582251 の反応式
[CH3:1][O:2][C:3]1[CH:9]=[CH:8][CH:7]=[CH:6][C:4]=1[NH2:5].[CH3:10][N:11]([CH2:15][CH2:16]O)[CH2:12][CH2:13]O.S(=O)(=O)(O)O>>[CH3:1][O:2][C:3]1[CH:9]=[CH:8][CH:7]=[CH:6][C:4]=1[NH2:5].[CH3:10][N:11]1[CH2:15][CH2:16][N:5]([C:4]2[CH:6]=[CH:7][CH:8]=[CH:9][C:3]=2[O:2][CH3:1])[CH2:13][CH2:12]1

参加物

5

反応物 3

HCID 1118Sulfuric AcidHCID 70002-MethoxyanilineHCID 7767N-Methyldiethanolamine

生成物 2

HCID 70002-MethoxyanilineHCID 98591201-(2-Methoxyphenyl)-4-methylpiperazine

実験手順

Here, 123 g of 2-methoxyaniline, 120 g of N-methyl-2,2'-iminodiethanol and 119 g of sulfuric acid, 100% strength, were employed. After a nitrogen pressure of 2 bar had been applied (final pressure 4.8 bar), the autoclave was kept at 160° C. for 15 h. Again, work-up was carried out as described in Example 1. 52.71 g of unreacted 2-methoxyaniline (bp. 740 to 80° C. at 1.3 to 1.7 mbar; Vigreux column 10 cm) and 52.1 g of N-methyl-N'-(2-methoxyphenyl)-piperazine (bp. 113° to 127° C. at 2.0 to 2.2 mbar) were obtained.

出典と根拠

ORDレコード
ord-c7a0177974324d8fa54f592619f167da
出典データセット
uspto-grants-1999_07
特許番号
US05922874

関連ノート

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