Water → 2-Methoxy-6-methylbenzoic acid

HRID 582371

反応式

HRID 582371 の反応式
[CH3:1][C:2]1[C:7]([C:8]([O:10]CC)=[O:9])=[C:6]([O:13][CH3:14])[CH:5]=[CH:4][CH:3]=1.O.[OH-].[Na+]>C(O)C>[CH3:1][C:2]1[C:7]([C:8]([OH:10])=[O:9])=[C:6]([O:13][CH3:14])[CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 5910602-Methoxy-6-methyl-benzoic acid ethyl ester

生成物 1

HCID 2731702-Methoxy-6-methylbenzoic acid

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of ethyl 6-methyl-2-methoxybenzoate (642.0 g, 3.3 mol), water (2.5 l), ethanol (4.0 l) and sodium hydroxide (270 g, 6.6 mol) is heated under reflux with stirring for 20 hours. Subsequently, ethanol is distilled off and the reaction mixture is diluted with water, acidified with concentrated hydrochloric acid. The solid material is collected by vacuum filtration, washed with water and dried yielding off-white crystals, 460.0 g (83.9%).

後処理

  1. temperatureis heated
  2. temperatureunder reflux
  3. distillationSubsequently, ethanol is distilled off
  4. additionthe reaction mixture is diluted with water
  5. filtrationThe solid material is collected by vacuum filtration
  6. washwashed with water
  7. customdried
  8. customyielding off-white crystals, 460.0 g (83.9%)

出典と根拠

ORDレコード
ord-07b0bba962794763b65a87b7bc7fd58d
出典データセット
uspto-grants-1999_07
特許番号
US05922905

関連ノート

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