Aniline → N-Phenyl-2-furancarboxamide

HRID 582440

反応式

HRID 582440 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(N(CC)CC)C.[O:15]1[CH:19]=[CH:18][CH:17]=[C:16]1[C:20](Cl)=[O:21]>ClCCl>[C:2]1([NH:1][C:20]([C:16]2[O:15][CH:19]=[CH:18][CH:17]=2)=[O:21])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 6115AnilineHCID 8471TriethylamineHCID 682422-Furancarbonyl chloride

生成物 1

HCID 220406N-Phenyl-2-furancarboxamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
-10 °C

実験手順

N-phenyl furamide was prepared by adding to a mixture of aniline (23.3 g; 250 mmol) and triethylamine (25.3 g; 250 mmol) in dichloromethane slowly 32.6 g (250 mmol) of 2-furoyl chloride, while maintaining the temperature at -10° C. The product obtained was washed with diluted hydrochloric acid and water, dried with magnesium sulphate and evaporated. The product so obtained was than triturated with hexane and filtered. 39.3 g (84% yield of product was recovered.

後処理

  1. customThe product obtained
  2. washwas washed with diluted hydrochloric acid and water
  3. dry with materialdried with magnesium sulphate
  4. customevaporated
  5. customThe product so obtained
  6. customthan triturated with hexane
  7. filtrationfiltered

出典と根拠

ORDレコード
ord-ec294cbabf8b4576be6a8b4d93a811ec
出典データセット
uspto-grants-1999_07
特許番号
US05925152

関連ノート

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