Sodium Hydroxide → 3-Oxo-2-[2-(pyridin-2-ylamino)ethyl]-2,3-dihydro-1-H-isoindole-5-carboxylic acid
反応式
C[O:2][C:3]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[CH2:10][N:9]([CH2:14][CH2:15][NH:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=1)[C:8]2=[O:23])=[O:4].[OH-].[Na+]>CO>[O:23]=[C:8]1[C:7]2[C:11](=[CH:12][CH:13]=[C:5]([C:3]([OH:4])=[O:2])[CH:6]=2)[CH2:10][N:9]1[CH2:14][CH2:15][NH:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=1参加物
4
実験手順
A methanol solution (50 ml) of 4-2 (2.6 g, 8.4 mmol) and 1 N NaOH (25.2 mL, 25.2 mmol) was stirred under ambient conditions for 18 h. The reaction was concentrated and the residue acidifed with 1 M NaHSO4 solution to provide 4-3 as a colorless solid.
後処理
- concentrationThe reaction was concentrated
出典と根拠
- ORDレコード
- ord-e6677f2eec144e239f44519e30ffa4d9
- 出典データセット
- uspto-grants-1999_07
- 特許番号
- US05925655
反応ノート
読み込み中…