Triethylamine → n-(2-Bromo-5-cyclopentyl-4-nitrophenyl)-4-methylbenzenesulphonamide

HRID 582774

反応式

HRID 582774 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([NH:10][S:11]([C:14]2[CH:19]=[CH:18][C:17]([CH3:20])=[CH:16][CH:15]=2)(=[O:13])=[O:12])=[CH:6][CH:5]=1)([O-:3])=[O:2].[CH:21]1([Mg]Cl)[CH2:25][CH2:24][CH2:23][CH2:22]1.[Br:28]Br.C(N(CC)CC)C>C1COCC1.CCOCC>[Br:28][C:8]1[CH:9]=[C:4]([N+:1]([O-:3])=[O:2])[C:5]([CH:21]2[CH2:25][CH2:24][CH2:23][CH2:22]2)=[CH:6][C:7]=1[NH:10][S:11]([C:14]1[CH:19]=[CH:18][C:17]([CH3:20])=[CH:16][CH:15]=1)(=[O:13])=[O:12]

参加物

7

反応物 4

HCID 8471TriethylamineHCID 24408BromineHCID 69772Benzenesulfonamide, 4-methyl-N-(4-nitrophenyl)-HCID 178478989HCID 178478989、化合物

生成物 1

HCID 22111914n-(2-Bromo-5-cyclopentyl-4-nitrophenyl)-4-methylbenzenesulphonamide

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

This compound is prepared according to the procedure described in step A of Preparation 2.18, from 15 g of N-(4-nitrophenyl)-4-methylbenzenesulphonamide in 100 ml of THF and 64 ml of a 2M solution of cyclopentylmagnesium chloride in ether, followed by 6.8 ml of bromine and 35 ml of triethylamine. 6.1 g of the expected product are obtained, m.p.=122° C.

後処理

  1. customThis compound is prepared

出典と根拠

ORDレコード
ord-bf68e7e6c65d4d468916fd7924fe50b8
出典データセット
uspto-grants-1999_07
特許番号
US05925661

関連ノート

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