Diethyl Ether → HCID 70244978、化合物

HRID 582783

反応式

HRID 582783 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([O:9][CH3:10])[C:4]=1[C:11]1[N:15]([C:16]2[CH:21]=[CH:20][C:19]([C:22](=[O:31])[N:23]([CH3:30])[CH2:24][CH2:25][CH2:26][N:27]([CH3:29])[CH3:28])=[CH:18][C:17]=2[CH:32]([CH3:34])[CH3:33])[N:14]=[C:13]([C:35]([NH:37][C:38]2([C:48]([OH:50])=[O:49])[CH:45]3[CH2:46][CH:41]4[CH2:42][CH:43]([CH2:47][CH:39]2[CH2:40]4)[CH2:44]3)=[O:36])[CH:12]=1.C[O-].[Na+:53].CCOCC>CO.C(Cl)Cl>[Na+:53].[CH3:10][O:9][C:5]1[CH:6]=[CH:7][CH:8]=[C:3]([O:2][CH3:1])[C:4]=1[C:11]1[N:15]([C:16]2[CH:21]=[CH:20][C:19]([C:22](=[O:31])[N:23]([CH3:30])[CH2:24][CH2:25][CH2:26][N:27]([CH3:28])[CH3:29])=[CH:18][C:17]=2[CH:32]([CH3:34])[CH3:33])[N:14]=[C:13]([C:35]([NH:37][C:38]2([C:48]([O-:50])=[O:49])[CH:39]3[CH2:40][CH:41]4[CH2:42][CH:43]([CH2:44][CH:45]2[CH2:46]4)[CH2:47]3)=[O:36])[CH:12]=1

参加物

6

反応物 3

HCID 3283Diethyl EtherHCID 5311451SR142948AHCID 10942334Sodium Methoxide

生成物 1

HCID 70244978HCID 70244978、化合物収率 70.6%

試薬・触媒・溶媒 2

HCID 6344Dichloromethane触媒HCID 887Methanol溶媒

反応条件

温度
5 °C

実験手順

0.206 g of the compound obtained in EXAMPLE 1' and 0.026 g of sodium methylate are dissolved in 1 ml of MeOH and a few drops of DCM, and this solution is then poured into 50 ml of ether cooled to 5° C. The gelatinous precipitate formed is drained and dried over P2O5 and under vacuum. 0.15 g of the expected product is obtained, m.p.=191° C.

後処理

  1. customThe gelatinous precipitate formed
  2. dry with materialdried over P2O5 and under vacuum

出典と根拠

ORDレコード
ord-41a11cde5d9041268bccfdadb4d9cc1e
出典データセット
uspto-grants-1999_07
特許番号
US05925661

関連ノート

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