Ethyl chloroacetate → Ethyl ethoxyacetate

HRID 582806

反応式

HRID 582806 の反応式
Cl[CH2:2][C:3]([O:5][CH2:6][CH3:7])=[O:4].[O-:8][CH2:9][CH3:10].[Na+]>C(O)C>[CH2:9]([O:8][CH2:2][C:3]([O:5][CH2:6][CH3:7])=[O:4])[CH3:10]

参加物

4

反応物 2

HCID 7751Ethyl chloroacetateHCID 2723922Sodium ethoxide

生成物 1

HCID 69955Ethyl ethoxyacetate収率 98.8%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of ethyl chloracetate (100 g, 99% pure, 0.81 mol) in ethanol is treated with ethanolic sodium ethoxide (282.9 g, 20.6% solution, 0.86 mole NaOC2H5) over a 1 hr period at 20° C.-30° C., heated at 40° C.-45° C. for 0.5 hr, cooled to room temperature, treated with diatomaceous earth, stirred for 0.25 hr and filtered. The filtercake is washed with ethanol. The combined filtrates are distilled to obtain the title product as a colorless liquid 75.78 g, 98.8% pure (71% yield), bp 87° C.-88° C./59 mmHg, identified by 13CNMR, 1HNMR and mass spectral analyses.

後処理

  1. temperatureheated at 40° C.-45° C. for 0.5 hr
  2. additiontreated with diatomaceous earth
  3. filtrationfiltered
  4. washThe filtercake is washed with ethanol
  5. distillationThe combined filtrates are distilled

出典と根拠

ORDレコード
ord-bf0c80d3ebdd46919339dbf745980f16
出典データセット
uspto-grants-1999_07
特許番号
US05925764

関連ノート

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