Hydrogen Bromide → 1-(1-Bromoethyl)-2,4-dichlorobenzene
反応式
[BrH:1].[Cl:2][C:3]1[CH:8]=[C:7]([Cl:9])[CH:6]=[CH:5][C:4]=1[CH:10](O)[CH3:11].O>CC(O)=O>[Br:1][CH:10]([C:4]1[CH:5]=[CH:6][C:7]([Cl:9])=[CH:8][C:3]=1[Cl:2])[CH3:11]参加物
5
反応条件
- 温度
- 0 °C
実験手順
15 ml of a 33% solution of HBr in AcOH are cooled to 0° C., 2 ml of 2,4-dichloro-1-(1-hydroxyethyl)benzene are added dropwise and the reaction mixture is stirred for 30 minutes at 0° C. and then for 3 hours at RT. It is poured into iced water and extracted with AcOEt, the organic phase is washed with saturated aqueous NaHCO3 solution, with water and with saturated NaCl solution and dried over MgSO4 and the solvent is evaporated off under vacuum to give 3.4 g of the expected product.
後処理
- waitfor 3 hours at RT
- extractionextracted with AcOEt
- washthe organic phase is washed with saturated aqueous NaHCO3 solution, with water and with saturated NaCl solution
- dry with materialdried over MgSO4
- customthe solvent is evaporated off under vacuum
出典と根拠
- ORDレコード
- ord-282ddd08c7094b82a49b2af700d2225f
- 出典データセット
- uspto-grants-1999_07
- 特許番号
- US05925768
反応ノート
読み込み中…