Hexadecanethiol → S-n-hexadecyl p-nitrophenylthiocarbamate

HRID 583015ノート

反応式

HRID 583015 の反応式
[CH2:1]([SH:17])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].[N+:18]([C:21]1[CH:26]=[CH:25][C:24]([N:27]=[C:28]=[O:29])=[CH:23][CH:22]=1)([O-:20])=[O:19]>C(#N)C>[N+:18]([C:21]1[CH:22]=[CH:23][C:24]([NH:27][C:28](=[O:29])[S:17][CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])=[CH:25][CH:26]=1)([O-:20])=[O:19]

参加物

4

反応物 2

HCID 18015HexadecanethiolHCID 66012Benzene, 1-isocyanato-4-nitro-

生成物 1

HCID 17762555S-n-hexadecyl p-nitrophenylthiocarbamate収率 97.1%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

In a three necked flask equipped with a dropping funnel, a thermometer and reflux condenser, n-hexadecanethiol (165 g) was dissolved in acetonitrile (1000 ml) in a nitrogen atmosphere. To the solution, p-nitrophenyl isocyanate (100 g) was gradually added, stirred at room temperature for 10 minutes, and then heat-refluxed for 30 minutes. The reaction liquid was cooled to room temperature to allow crystals to precipitate. The crystals were collected by filtering and washed with acetonitrile, to obtain S-n-hexadecyl p-nitrophenylthiocarbamate (250 g) at a yield of 97%.

後処理

  1. customIn a three necked flask equipped with a dropping funnel
  2. temperaturea thermometer and reflux condenser
  3. temperatureheat-refluxed for 30 minutes
  4. customThe reaction liquid
  5. temperaturewas cooled to room temperature
  6. customto precipitate
  7. customThe crystals were collected
  8. filtrationby filtering
  9. washwashed with acetonitrile

出典と根拠

ORDレコード
ord-c299eda7db9b4283bf2016743ef4e09b
出典データセット
uspto-grants-1999_07
特許番号
US05928988

反応ノート

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