Hydrochloric Acid → HCID 21226466、化合物

反応式

[OH-].[Na+].C([O:6][CH2:7][C:8]1[CH:9]=[C:10]([C:15]2[C:19]([Cl:20])=[C:18]([O:21][CH:22]([F:24])[F:23])[N:17]([CH3:25])[N:16]=2)[CH:11]=[CH:12][C:13]=1[Cl:14])(=O)C.Cl>O1CCOCC1.O>[Cl:20][C:19]1[C:15]([C:10]2[CH:11]=[CH:12][C:13]([Cl:14])=[C:8]([CH2:7][OH:6])[CH:9]=2)=[N:16][N:17]([CH3:25])[C:18]=1[O:21][CH:22]([F:24])[F:23]

参加物

実験手順

6.3 ml (16 mmol) of 10% strength sodium hydroxide solution were added dropwise to a solution of 3.2 g (8.8 mmol) of 3-(3-acetoxymethyl-4-chlorophenyl)-4-chloro-5-difluoromethoxy-1-methyl-1H-pyrazole in 10 ml of dioxane and 10 ml of water. The mixture was stirred for 1 hour and then neutralized with 3N hydrochloric acid. The product was extracted from the aqueous phase with ethyl acetate, after which the organic phase was dried over magnesium sulfate and then concentrated. The crude product thus obtained was purified by column chromography on silica gel (eluent: hexane/ethyl acetate=4:1). Yield: 1.3 g.