Diisopropylethylamine → {4-[(4-{[Amino(imino)methyl](methyl)amino}butanoyl)amino]butyl}(triphenyl)phosphonium bromide

HRID 58342ノート

反応式

HRID 58342 の反応式
[Br-:1].CNCCC[C:7]([NH:9][CH2:10][CH2:11][CH2:12][CH2:13][P+:14]([C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:8].Cl.[N:34]1([C:39](=[NH:41])[NH2:40])[CH:38]=[CH:37][CH:36]=N1.[CH:42](N(CC)C(C)C)(C)C>CN(C)C=O>[Br-:1].[NH2:40][C:39]([N:34]([CH3:42])[CH2:38][CH2:37][CH2:36][C:7]([NH:9][CH2:10][CH2:11][CH2:12][CH2:13][P+:14]([C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)([C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[O:8])=[NH:41]

参加物

5

反応物 3

HCID 81531Diisopropylethylamine2 回HCID 2734672Pyrazole-1-carboxamidine monohydrochloride2 回HCID 89462815(4-{[4-(Methylamino)butanoyl]amino}butyl)(triphenyl)phosphonium bromide

生成物 1

HCID 117774922{4-[(4-{[Amino(imino)methyl](methyl)amino}butanoyl)amino]butyl}(triphenyl)phosphonium bromide

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

(4-{[4-(methylamino)butanoyl]amino}butyl)(triphenyl)phosphonium bromide (690 mg, 1.30 mmol) was dissolved in N,N-dimethylformamide (1.4 mL). The resultant solution was treated with 1H-pyrazole-1-carboximidamide hydrochloride (216 mg, 1.47 mmol) and N,N-diisopropylethylamine (0.27 mL, 1.54 mmol). The reaction was stirred overnight at room temperature. More 1H-pyrazole-1-carboximidamide hydrochloride and N,N-diisopropylethylamine can be added to effect further conversion. The reaction mixture in N,N-dimethylformamide was used in the purification without isolation.

後処理

  1. customThe reaction mixture in N,N-dimethylformamide was used in the purification without isolation

出典と根拠

ORDレコード
ord-f5fa93a8df8944bb8766fa34ca559747
出典データセット
uspto-grants-2016_09
特許番号
US09434753B2

反応ノート

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