[C:1]([O:5][C:6](=[O:37])[C@@H:7]([NH:27][S:28]([C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)(=[O:30])=[O:29])[CH2:8][NH:9][C:10](=[O:26])[C:11]1[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH2:19][NH:20][C:21]2[S:22][CH:23]=[CH:24][N:25]=2)=[CH:13][CH:12]=1)(C)(C)[CH3:2].[C:38](O)([C:40](F)(F)F)=[O:39]>C(Cl)Cl>[CH3:2][CH2:1][O:5][C:6]([CH3:7])=[O:37].[CH3:40][CH2:38][OH:39].[NH4+:9].[OH-:5].[OH2:5].[S:22]1[CH:23]=[CH:24][N:25]=[C:21]1[NH:20][CH2:19][CH2:18][O:17][C:14]1[CH:13]=[CH:12][C:11]([C:10]([NH:9][CH2:8][C@H:7]([NH:27][S:28]([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)(=[O:30])=[O:29])[C:6]([OH:37])=[O:5])=[O:26])=[CH:16][CH:15]=1Ester 24-6 (197 mg, 0.36 mmol) was dissolved in 1.8 mL CH2Cl2 and treated with 1.8 mL TFA. Once the starting material had disappeared, the reaction was concentrated, and flash chromatography (silica, 18:10:1:1 EtOAc/EtOH/NH4OH/H2O) provided 24-7 as a white solid. Rf 0.26 (silica, 18:10:1:1 EtOAc/EtOH/NH4OH/H2O).
読み込み中…