Trifluoroacetic acid → 4-[2-(Pyrimidin-2-ylamino)ethyloxy]benzoyl-2(S)-benzyloxycarbonyl-amino-beta-alanine

HRID 583697ノート

反応式

HRID 583697 の反応式
C([O:5][C:6](=[O:39])[C@H:7]([C:29]([O:31][CH2:32][C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)=[O:30])[CH2:8][N:9]([C:11](=[O:28])[C:12]1[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][NH:21][C:22]2[N:27]=[CH:26][CH:25]=[CH:24][N:23]=2)=[CH:14][CH:13]=1)[NH2:10])(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[N:23]1[CH:24]=[CH:25][CH:26]=[N:27][C:22]=1[NH:21][CH2:20][CH2:19][O:18][C:15]1[CH:14]=[CH:13][C:12]([C:11]([N:9]([NH2:10])[CH2:8][C@H:7]([C:29]([O:31][CH2:32][C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)=[O:30])[C:6]([OH:39])=[O:5])=[O:28])=[CH:17][CH:16]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 86752454HCID 86752454、化合物

生成物 1

HCID 867524534-[2-(Pyrimidin-2-ylamino)ethyloxy]benzoyl-2(S)-benzyloxycarbonyl-amino-beta-alanine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of 25-1 (840 mg, 1.6 mmol) and CH2Cl2 (10 ml) at ambient temperature was treated with TFA (10 ml). After stirring for 4.0 h, the reaction mixture was concentrated and the residual TFA removed azeotropically with toluene. Trituration of the resulting waxy solid with ether provided 25-2 as a white solid.

後処理

  1. concentrationthe reaction mixture was concentrated
  2. customthe residual TFA removed azeotropically with toluene

出典と根拠

ORDレコード
ord-80066096a3bb4c9f96febc334fe8bfc4
出典データセット
uspto-grants-1999_07
特許番号
US05929120

反応ノート

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