関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2,2-Dibromopropane | HCID 11658 | — |
| 反応物 | HCID 12116531 | HCID 12116531 | — |
| 溶媒 | pentanol DMF | HCID 86593149 | — |
| 生成物 | HCID 178526667 | HCID 178526667 | 189.3% |
反応手順
3.5 g (0.0135 mol) of 1-[1-(4-nitrophenyl)pyrrolidin-3-yl]-1H-imidazole were heated to 100° C. in 12 ml of a pentanol/DMF mixture (50/50). 1 g (0.005 mol) of dibromopropane was added. The reaction medium was heated at 115° C. for 17 hours. The precipitate was filtered off while hot and washed with pentanol and then with ether. After draining by suction and drying the precipitate, 3.4 g of yellow powder (4) were obtained. 33% yield.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06923835B2 |
|---|
| 出典データセット | uspto-grants-2005_08 |
|---|
| ORD ID | ord-387f92f2044842899763467dfed4b438 |
|---|
| 出典メモ | uspto-grants-2005_08 |
|---|
