HCID 86591771、化合物 → HCID 69545606、化合物
反応式
[N:1]([CH:4]1[CH2:8][N:7]([C:9](=[O:27])[CH2:10][CH2:11][C:12]2[CH:17]=[CH:16][C:15]([CH2:18][NH:19][C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])=[CH:14][CH:13]=2)[C@H:6]([C:28]([O:30][CH3:31])=[O:29])[CH2:5]1)=[N+]=[N-]>CO.[Pd]>[NH2:1][CH:4]1[CH2:8][N:7]([C:9](=[O:27])[CH2:10][CH2:11][C:12]2[CH:13]=[CH:14][C:15]([CH2:18][NH:19][C:20]([O:22][C:23]([CH3:26])([CH3:24])[CH3:25])=[O:21])=[CH:16][CH:17]=2)[C@H:6]([C:28]([O:30][CH3:31])=[O:29])[CH2:5]1参加物
4
実験手順
6.27 g of methyl 4-azido-1-[3-(4-tert-butyloxycarbonylaminomethylphenyl)propionyl]prolinate (starting material A5) are dissolved in 200 ml of methanol and, after addition of 0.6 g of Pd/C (10%), hydrogenated. After the reaction has ended, the catalyst is filtered off with suction and the filtrate is concentrated under reduced pressure. Drying under high vacuum gives 5.47 g of the title compound as a colorless solidified foam. The mass spectrum shows the molecular peak MH+ at 406 Da.