Acetic Acid → 4-(Methylsulfonyl)benzonitrile

HRID 584125

反応式

HRID 584125 の反応式
CS[C:3]1[CH:10]=[CH:9][C:6]([C:7]#[N:8])=[CH:5][CH:4]=1.[Mn]([O-])(=O)(=O)=O.[K+].[OH:17][S:18]([O-:20])=O.[Na+].[CH3:22]C(O)=O>>[CH3:22][S:18]([C:3]1[CH:10]=[CH:9][C:6]([C:7]#[N:8])=[CH:5][CH:4]=1)(=[O:20])=[O:17]

参加物

5

反応物 4

HCID 176Acetic AcidHCID 516875Potassium PermanganateHCID 5909604-(Methylthio)benzonitrileHCID 23665763Sodium Bisulfite

生成物 1

HCID 5199814-(Methylsulfonyl)benzonitrile収率 82%

実験手順

4-Methylsulfanyl-benzonitrile (250 mg, 1.68 mmol) was dissolved in 12 mL of HOAc. Potassium permanganate (531 mg, 3.36 mmol) was added as an aqueous solution (7-8 mL). After stirring 30 min at RT, NaHSO3 was added with stirring until the brown color of the solution disappeared. The mixture was concentrated and diluted with water. The precipitate was filtered and dried in vacuo to yield 4-methanesulfonyl-benzonitrile (250 mg, 82%) which was used without further purification.

後処理

  1. stirringwith stirring until the brown color of the solution
  2. concentrationThe mixture was concentrated
  3. additiondiluted with water
  4. filtrationThe precipitate was filtered
  5. customdried in vacuo

出典と根拠

ORDレコード
ord-9846733ca9f24b588cde6fd012db9f92
出典データセット
uspto-grants-2005_08
特許番号
US06924284B2

関連ノート

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