Methanesulfinic acid → HCID 9862981、化合物

HRID 584663ノート

反応式

HRID 584663 の反応式
Cl[C:2]1[C:11]([C:12]([F:15])([F:14])[F:13])=[N:10][C:9]2[C:4](=[CH:5][C:6]([Cl:17])=[C:7]([Cl:16])[CH:8]=2)[N:3]=1.[CH3:18][S:19]([OH:21])=[O:20].[Na]>CN(C=O)C>[Cl:16][C:7]1[CH:8]=[C:9]2[C:4](=[CH:5][C:6]=1[Cl:17])[N:3]=[C:2]([S:19]([CH3:18])(=[O:21])=[O:20])[C:11]([C:12]([F:15])([F:14])[F:13])=[N:10]2

参加物

5

反応物 3

HCID 87251Methanesulfinic acidHCID 5360545SodiumHCID 223410732,6,7-Trichloro-3-(trifluoromethyl)quinoxaline

生成物 1

HCID 9862981HCID 9862981、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a solution of 2,6,7-trichloro-3-trifluoromethylquinoxaline (64 mg, 0.2 mmol) in DMF (1 ml) was added methanesulfinic acid, sodium salt (43 mg, 0.4 mmol). The reaction mixture was stirred at room temperature overnight, then it was partitioned between ethyl acetate and water. The organic layer was separated and concentrated to an oil. This oil was further purified by column chromatography (ethyl acetate:hexanes 1:3) to yield the title compound as a white solid.

後処理

  1. customit was partitioned between ethyl acetate and water
  2. customThe organic layer was separated
  3. concentrationconcentrated to an oil
  4. customThis oil was further purified by column chromatography (ethyl acetate:hexanes 1:3)

出典と根拠

ORDレコード
ord-0550dabd66cb443ab3c91089aeceef56
出典データセット
uspto-grants-2005_08
特許番号
US06927214B1

反応ノート

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