Lithium hydroxide, monohydrate → HCID 178524764、化合物
反応式
[OH:1][C:2]1[C:7]([C:8]([O:10]CC)=[O:9])=[CH:6][N:5]=[CH:4][N:3]=1.O[Li].O>C1COCC1.CO>[OH:1][C:2]1[C:7]([C:8]([OH:10])=[O:9])=[CH:6][N:5]=[CH:4][N:3]=1参加物
5
実験手順
Ethyl 4-hydroxypyrimidine-5-carboxylate can be prepared following the procedure of M. Pesson et al., Eur. J. Med. Chem.—Chim. Ther. 1974, 9, 585. A solution of this ester (500 mg, 3 mmol) in THF (10 mL) and MeOH (5mL) was treated with LiOH.H2O (373 mg, 8.9 mmol) and stirred overnight. The mixture was quenched with conc. HCl (1 mL) and extracted with EtOAc (2×20 mL). The combined organic extract was dried (MgSO4) and concentrated to give 260 mg of the title compound 19 as an orange solid, m.p. 220° C. (dec). 4-Hydroxy-2-methylpyrimidine-5-carboxylic Acid (20).
後処理
- customThe mixture was quenched with conc. HCl (1 mL)
- extractionextracted with EtOAc (2×20 mL)
- extractionThe combined organic extract
- dry with materialwas dried (MgSO4)
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-fa8220878f0a4f129f5a879f952e56e9
- 出典データセット
- uspto-grants-2005_08
- 特許番号
- US06927225B2
反応ノート
読み込み中…