Thionyl Chloride → HCID 178424660、化合物
反応式
S(Cl)([Cl:3])=O.O[CH2:6][CH2:7][C:8]1[C:9]([CH3:28])=[N:10][C:11]2[N:12]([C:15]([CH3:27])=[N:16][C:17]=2[C:18]2[C:23]([CH3:24])=[CH:22][C:21]([CH3:25])=[CH:20][C:19]=2[CH3:26])[C:13]=1[OH:14]>C1(C)C=CC=CC=1>[Cl:3][CH2:6][CH2:7][C:8]1[C:9]([CH3:28])=[N:10][C:11]2[N:12]([C:15]([CH3:27])=[N:16][C:17]=2[C:18]2[C:23]([CH3:24])=[CH:22][C:21]([CH3:25])=[CH:20][C:19]=2[CH3:26])[C:13]=1[OH:14]参加物
4
実験手順
Thionyl chloride (112 mL, 1.54 mmol) was added to a solution of 3-(2-hydroxyethyl)-8-mesityl-2,6-dimethylimidazo[1,5-a]pyrimidin-4-ol (500 mg, 1.54 mmol) in toluene (5 mL) at 80° C., followed by stirring for one hour. After cooling to room temperature, the resulting crystals were washed with diethyl ether, to give the title compound (360 mg) as pale brown crystals.