2-Bromo-5-nitrobenzoic acid → 5-Amino-2-bromobenzoic acid

HRID 584861

反応式

HRID 584861 の反応式
[Br:1][C:2]1[CH:10]=[CH:9][C:8]([N+:11]([O-])=O)=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[H][H]>CO.[Pd]>[NH2:11][C:8]1[CH:9]=[CH:10][C:2]([Br:1])=[C:3]([CH:7]=1)[C:4]([OH:6])=[O:5]

参加物

5

反応物 2

HCID 2430252-Bromo-5-nitrobenzoic acidHCID 178418361HCID 178418361、化合物

生成物 1

HCID 27696245-Amino-2-bromobenzoic acid収率 91.2%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A mixture of 2-bromo-5-nitrobenzoic acid (1.10 g, 4.06 mmol) (Aldrich, 38, 184-5), activated Pd—C (43.62 mg, 0.41 mmol) (Aldrich, 20, 569-9) in methanol (30 ml) was hydrogenated for 4 hr under 30 psi of hydrogen pressure. After the mixture was filtered, the filtrate was concentrated to give 0.80 g (91.2% yield) of 5-amino-2-bromobenzoic acid as a pale yellow solid.

後処理

  1. filtrationAfter the mixture was filtered
  2. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-6f9c76d053394dd9bed2be85889dee2e
出典データセット
uspto-grants-2005_08
特許番号
US06927303B2

関連ノート

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