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4-Formylphenylboronic Acid → Tert-butyl (4'-formylbiphenyl-3-ylmethyl)methylcarbamate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Formylphenylboronic Acid | HCID 591073 | — |
| 反応物 | tert-Butyl 3-bromobenzyl(methyl)carbamate | HCID 20738487 | — |
| 生成物 | Tert-butyl (4'-formylbiphenyl-3-ylmethyl)methylcarbamate | HCID 86591268 | — |
反応手順
In a manner similar to that of Example 1(e), by reacting 38 g (127 mmol) of tert-butyl (3-bromo benzyl)-N-methylcarbamate obtained in Example 79(b) with 25.6 g (170 mmol) of 4-formylbenzene boronic acid, and after purification by chromatography on a column of silica eluted with a heptane/ethyl acetate mixture (9/1), 20 g (57%) of the expected product are obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06927228B2 |
| 出典データセット | uspto-grants-2005_08 |
| ORD ID | ord-a89609cff2d8439b9bd4f54bf526b5ef |
| 出典メモ | uspto-grants-2005_08 |