反応式
[OH:1][CH2:2][C:3]1[O:7][N:6]=[C:5]([C:8]([O:10]CC)=[O:9])[CH:4]=1.[OH-].[Na+].Cl>[Cl-].[Na+].O>[OH:1][CH2:2][C:3]1[O:7][N:6]=[C:5]([C:8]([OH:10])=[O:9])[CH:4]=1参加物
5
実験手順
The mixture of Ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate (1.5 g; 8.76 mmol) and 1M sodium hydroxide (18 mL; 18 mmol) was stirred at room temperature for 3.5 h. Brine (40 mL) was added and the pH of the solution was adjusted to 2 by addition of 6N hydrochloric acid. The acidic solution was extracted with 8×60 mL of ethyl acetate. Organic extracts were dried over magnesium sulfate. Evaporation of the solvent produced 1.20 g (95%) of 5-(hydroxymethyl)isoxazole-3-carboxylic acid as a white solid, which was used without further purification.
後処理
- extractionThe acidic solution was extracted with 8×60 mL of ethyl acetate
- dry with materialOrganic extracts were dried over magnesium sulfate
- customEvaporation of the solvent
出典と根拠
- ORDレコード
- ord-b5e24eeb7fe74ff3985ea234d6d4e487
- 出典データセット
- uspto-grants-2016_09
- 特許番号
- US09434722B2
関連ノート
読み込み中…