2-Isoxazoline-3-carboxylic acid, 5-phenyl-, ethyl ester → 5-Phenyl-4,5-dihydro-1,2-oxazole-3-carboxylic acid

HRID 58536

反応式

HRID 58536 の反応式
[C:1]1([CH:7]2[O:11][N:10]=[C:9]([C:12]([O:14]CC)=[O:13])[CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>[OH-].[Na+].O1CCOCC1>[C:1]1([CH:7]2[O:11][N:10]=[C:9]([C:12]([OH:14])=[O:13])[CH2:8]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

4

反応物 1

HCID 5388222-Isoxazoline-3-carboxylic acid, 5-phenyl-, ethyl ester

生成物 1

HCID 130815325-Phenyl-4,5-dihydro-1,2-oxazole-3-carboxylic acid

試薬・触媒・溶媒 2

HCID 14798Sodium Hydroxide溶媒HCID 312751,4-Dioxane溶媒

実験手順

Ethyl 5-phenyl-4,5-dihydroisoxazole-3-carboxylate (0.1 g; 0.4 mmol) was dissolved in a mixture of sodium hydroxide (5 mL, 1M, water) and dioxane (2 mL). The reaction mixture was stirred vigorously at room temperature overnight and concentrated under reduced pressure. The resulting solution was acidified and extracted with ethyl acetate, dried and concentrated under reduced pressure, the crude material was used without further purification.

後処理

  1. concentrationconcentrated under reduced pressure
  2. extractionextracted with ethyl acetate
  3. customdried
  4. concentrationconcentrated under reduced pressure
  5. customthe crude material was used without further purification

出典と根拠

ORDレコード
ord-ab4ec2da78fa428b9c4bb3e01e132049
出典データセット
uspto-grants-2016_09
特許番号
US09434722B2

関連ノート

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