4-Ethylaniline → 1-(4-Ethylphenyl)-2-oxopyrrolidine-3-carboxylic acid
反応式
[CH2:1]([C:3]1[CH:9]=[CH:8][C:6]([NH2:7])=[CH:5][CH:4]=1)[CH3:2].CC1(C)[O:18][C:17](=O)[C:14]2([CH2:16][CH2:15]2)[C:13](=[O:20])[O:12]1>C(O)C>[CH2:1]([C:3]1[CH:9]=[CH:8][C:6]([N:7]2[CH2:16][CH2:15][CH:14]([C:13]([OH:20])=[O:12])[C:17]2=[O:18])=[CH:5][CH:4]=1)[CH3:2]参加物
4
実験手順
A mixture of 4-ethylaniline (1.1 mL; 8.73 mmol) and 6,6-dimethyl-5,7-dioxaspiro[2.5]octane-4,8-dione (0.5 g; 2.94 mmol) in ethanol (3 mL) was irradiated in a microwave oven for 3 minutes at 100° C. and concentrated under reduced pressure. The crude material was purified by flash chromatography on silica gel (eluent 10 to 80% ethyl acetate in heptane with 5% acetic acid) to afford 1-(4-ethylphenyl)-2-oxopyrrolidine-3-carboxylic acid 0.453 g (67%).
後処理
- customwas irradiated in a microwave oven for 3 minutes at 100° C.
- concentrationconcentrated under reduced pressure
- customThe crude material was purified by flash chromatography on silica gel (eluent 10 to 80% ethyl acetate in heptane with 5% acetic acid)
出典と根拠
- ORDレコード
- ord-aeac813c1bfe482e83bc233d1332b796
- 出典データセット
- uspto-grants-2016_09
- 特許番号
- US09434722B2
反応ノート
読み込み中…