Ethylene Glycol → 2-Bromo-4-(1,3-dioxolan-2-yl)thiazole
反応式
[Br:1][C:2]1[S:3][CH:4]=[C:5]([CH:7]=[O:8])[N:6]=1.[CH2:9](O)[CH2:10][OH:11]>C1(C)C=CC=CC=1>[Br:1][C:2]1[S:3][CH:4]=[C:5]([CH:7]2[O:11][CH2:10][CH2:9][O:8]2)[N:6]=1参加物
4
実験手順
2-Bromothiazole-4-carbaldehyde (6.56 g, 34.17 mmol) [A. T. Ung, S. G. Pyne/Tetrahedron: Asymmetry 9 (1998) 1395-1407] and ethylene glycol (5.72 ml, 102.5 mmol) were heated under reflux in toluene (50 ml) ,with a Dean and Stark trap fitted, for 18 hr. The product was concentrated and purified by column chromatography (15% ethyl acetate Ihexane) to give the product as a yellow solid (6.03 g); m/z 236,238.
後処理
- customa Dean and Stark trap fitted, for 18 hr
- concentrationThe product was concentrated
- custompurified by column chromatography (15% ethyl acetate Ihexane)
出典と根拠
- ORDレコード
- ord-fc85e00916774a68a37efb6790737cfd
- 出典データセット
- uspto-grants-2005_08
- 特許番号
- US06933299B1
反応ノート
読み込み中…