Potassium Nitrate → 5-Bromo-8-nitroisoquinoline

HRID 585911

反応式

HRID 585911 の反応式
[Br:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][N:6]=[CH:7]2.[N+:12]([O-])([O-:14])=[O:13].[K+]>[OH-].[NH4+]>[Br:1][C:2]1[CH:11]=[CH:10][C:9]([N+:12]([O-:14])=[O:13])=[C:8]2[C:3]=1[CH:4]=[CH:5][N:6]=[CH:7]2

参加物

4

反応物 2

HCID 24434Potassium NitrateHCID 7364875-Bromoisoquinoline

生成物 1

HCID 8169835-Bromo-8-nitroisoquinoline

試薬・触媒・溶媒 1

HCID 14923Ammonium Hydroxide溶媒

実験手順

The diethyl ether solution from Example 57A was treated with potassium nitrate (10.1 g, 100 mmol). After stirring for one hour, The mixture was poured onto ice and neutralized with concentrated ammonium hydroxide (˜300 ml). The crude product was collected by filtration, dried, and recrystalization from methanol to provide the title compound (8.83 g).

後処理

  1. filtrationThe crude product was collected by filtration
  2. customdried
  3. customrecrystalization from methanol

出典と根拠

ORDレコード
ord-8378bd2b8abd47ef93fa966ae2e38faa
出典データセット
uspto-grants-2005_08
特許番号
US06933311B2

関連ノート

読み込み中…