3,4-Dimethylaniline → 1-(3,4-Dimethylphenyl)-2-oxopyrrolidine-3-carboxylic acid

HRID 58597

反応式

HRID 58597 の反応式
CC1(C)[O:9][C:8](=[O:10])[C:5]2([CH2:7][CH2:6]2)[C:4](=[O:11])O1.[CH3:13][C:14]1[CH:15]=[C:16]([CH:18]=[CH:19][C:20]=1[CH3:21])[NH2:17]>C(O)C>[CH3:13][C:14]1[CH:15]=[C:16]([N:17]2[CH2:6][CH2:7][CH:5]([C:8]([OH:9])=[O:10])[C:4]2=[O:11])[CH:18]=[CH:19][C:20]=1[CH3:21]

参加物

4

反応物 2

HCID 72483,4-DimethylanilineHCID 797206,6-Dimethyl-5,7-dioxaspiro(2.5)octane-4,8-dione

生成物 1

HCID 242752121-(3,4-Dimethylphenyl)-2-oxopyrrolidine-3-carboxylic acid収率 86.3%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

This compound was prepared according to general method 1 starting from 6,6-dimethyl-5,7-dioxaspiro[2.5]octane-4,8-dione (0.250 g; 1.45 mmol) and 3,4-dimethylaniline (0.540 g; 4.36 mmol) in ethanol (3 mL). 1-(3,4-dimethylphenyl)-2-oxopyrrolidine-3-carboxylic acid 0.292 g (86%) was obtained as a white solid.

後処理

  1. customThis compound was prepared

出典と根拠

ORDレコード
ord-262dbf38dde742b0b51facbf862dca32
出典データセット
uspto-grants-2016_09
特許番号
US09434722B2

関連ノート

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