Water → Ethyl 5-(3,4-dimethoxybenzyl)-1,2,4-oxadiazole-3-carboxylate

HRID 58612

反応式

HRID 58612 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:11][C:12](Cl)=[O:13])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].[NH2:15][C:16](=[N:22]O)[C:17]([O:19][CH2:20][CH3:21])=[O:18].C(N(CC)C(C)C)(C)C.O>ClCCl>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:6]=[CH:7][C:8]=1[O:9][CH3:10])[CH2:11][C:12]1[O:13][N:22]=[C:16]([C:17]([O:19][CH2:20][CH3:21])=[O:18])[N:15]=1

参加物

6

反応物 4

HCID 962WaterHCID 81531DiisopropylethylamineHCID 3604458(3,4-Dimethoxyphenyl)acetyl chlorideHCID 6785548Ethyl 2-amino-2-(hydroxyimino)acetate

生成物 1

HCID 63379366Ethyl 5-(3,4-dimethoxybenzyl)-1,2,4-oxadiazole-3-carboxylate収率 36%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

2-(3,4-dimethoxyphenyl)acetyl chloride (0.650 mL; 3.78 mmol) was added to a mixture of ethyl 2-amino-2-(hydroxyimino)acetate (0.500 g; 3.78 mmol) and N,N diisopropylethylamine (1.05 mL; 6.06 mmol) in dichloromethane (18 mL) at −15° C. The reaction mixture was stirred at room temperature overnight and poured into a mixture of ice and water. The formed precipitate was filtered off, suspended in pyridine (18 mL) and refluxed in a sealed tube for 20 h and concentrated under reduced pressure. The crude material was purified by flash chromatography on silica (eluent 20 to 100% ethyl acetate in heptane) to yield 0.395 g (36%) of ethyl 5-(3,4-dimethoxybenzyl)-1,2,4-oxadiazole-3-carboxylate as a yellow solid.

後処理

  1. filtrationThe formed precipitate was filtered off
  2. temperaturerefluxed in a sealed tube for 20 h
  3. concentrationconcentrated under reduced pressure
  4. customThe crude material was purified by flash chromatography on silica (eluent 20 to 100% ethyl acetate in heptane)

出典と根拠

ORDレコード
ord-a13d806b86a04085aa57639ff4b4e83f
出典データセット
uspto-grants-2016_09
特許番号
US09434722B2

関連ノート

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