Methyl iodide → HCID 22329483、化合物

HRID 586315

反応式

HRID 586315 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([C:8]2[NH:12][N:11]=[CH:10][N:9]=2)[CH:5]=[CH:6][CH:7]=1.[C:13]([O-])([O-])=O.[K+].[K+].CI>>[Br:1][C:2]1[CH:3]=[C:4]([C:8]2[N:12]([CH3:13])[N:11]=[CH:10][N:9]=2)[CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 124615465-(3-Bromophenyl)-1H-1,2,4-triazole

生成物 1

HCID 22329483HCID 22329483、化合物収率 11.1%

実験手順

This reaction was carried out as described in Example 40, step c, using 5-(3-bromophenyl)-1H-[1,2,4]triazole (1.60 g, 7.2 mmol), K2CO3 (2.47 g, 17.8 mmol) and MeI (667 μl, 10.7 mmol). The residue was purified by column chromatography (silica gel, 80% Et2O/isohexane) to yield first 5-(3-bromophenyl)-1-methyl-1H-[1,2,4]triazole (190 mg, 11%), and then the solvent polarity was increased to 100% EtOAc to yield 3-(3-bromophenyl)-1-methyl-1H-[1,2,4]triazole (935 mg, 55%).

後処理

  1. customThe residue was purified by column chromatography (silica gel, 80% Et2O/isohexane)

出典と根拠

ORDレコード
ord-b494b8b8445f4135a191a3fa043a52c1
出典データセット
uspto-grants-2005_08
特許番号
US06936608B2

関連ノート

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