Iodoethane → HCID 69738490、化合物

反応式

[CH3:1][O:2][CH2:3][CH:4]1[C@H:6]([CH2:7][OH:8])[C:5]1([CH3:23])[C:9]1[CH:18]=[CH:17][C:16]2[C:15]([CH3:20])([CH3:19])[CH2:14][CH2:13][C:12]([CH3:22])([CH3:21])[C:11]=2[CH:10]=1.[Si](OCC1[C@@H](CO)C1(C)C1C=CC2C(C)(C)CCC(C)(C)C=2C=1)(C(C)(C)C)(C)[CH3:25].C(I)C>>[CH2:1]([O:2][CH2:3][CH:4]1[C@@H:6]([CH2:7][OH:8])[C:5]1([CH3:23])[C:9]1[CH:18]=[CH:17][C:16]2[C:15]([CH3:20])([CH3:19])[CH2:14][CH2:13][C:12]([CH3:22])([CH3:21])[C:11]=2[CH:10]=1)[CH3:25]

参加物

反応物 3

HCID 6340Iodoethane

HCID 69738373HCID 69738373、化合物

HCID 131725079HCID 131725079、化合物

生成物 1

HCID 69738490HCID 69738490、化合物収率 81%

実験手順

Following a procedure similar to that for the preparation of Intermediate 6a using Intermediate 5 as the starting material and ethyl iodide as the alkylating reagent provided the title compound (65 mg, 81% yield) as a colorless oil:

出典と根拠

ORDレコード: ord-921ffc8b63714c6680fb4a5eb3712295
出典データセット: uspto-grants-2005_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06936636B2

反応ノート

読み込み中…