Nitric Acid → 2,4-Diisopropyl-1-nitrobenzene

HRID 586676

反応式

HRID 586676 の反応式
[N+:1]([O-:4])(O)=[O:2].[CH:5]([C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([CH:14]([CH3:16])[CH3:15])[CH:9]=1)([CH3:7])[CH3:6]>C(O)(=O)C.C(OC(=O)C)(=O)C.O.CCCCCC>[CH:5]([C:8]1[CH:9]=[C:10]([CH:14]([CH3:16])[CH3:15])[CH:11]=[CH:12][C:13]=1[N+:1]([O-:4])=[O:2])([CH3:7])[CH3:6]

参加物

7

反応物 2

HCID 944Nitric AcidHCID 74501,3-Diisopropylbenzene

生成物 1

HCID 223357262,4-Diisopropyl-1-nitrobenzene収率 98%

試薬・触媒・溶媒 4

HCID 176Acetic Acid溶媒HCID 962Water溶媒HCID 7918Acetic Anhydride溶媒HCID 8058Hexane溶媒

実験手順

Nitric acid (70%) (15.6 g, 185 mmol) was added slowly to a solution of 1,3-di-iso-propyl-benzene (available from Aldrich) (20 g, 123 mmol) in acetic acid (50 mL) and acetic anhydride (50 mL) at 0° C. over 20 min. After stirring at room temperature for 1 hour, the reaction mixture was diluted with water (250 mL) and hexane (500 mL). The organic layer was then washed with with water (50 mL), saturated Na2CO3 (50 mL), dried (Na2SO4) and concentrated to give the title compound in a crude form (25 g, 98% yield) as a colorless oil:

後処理

  1. washThe organic layer was then washed with with water (50 mL), saturated Na2CO3 (50 mL)
  2. dry with materialdried (Na2SO4)
  3. concentrationconcentrated

出典と根拠

ORDレコード
ord-e4a5090f80d14d719bf6c304ea57d41b
出典データセット
uspto-grants-2005_08
特許番号
US06936636B2

関連ノート

読み込み中…