1-Bromo-2-butanone → Formyl(2-oxobutyl)formamide

HRID 586709ノート

反応式

HRID 586709 の反応式
Br[CH2:2][C:3](=[O:6])[CH2:4][CH3:5].[CH:7]([N-:9][CH:10]=[O:11])=[O:8].[Na+]>C(#N)C>[CH:7]([N:9]([CH2:2][C:3](=[O:6])[CH2:4][CH3:5])[CH:10]=[O:11])=[O:8]

参加物

4

反応物 2

HCID 131561-Bromo-2-butanoneHCID 10877056Sodium Diformylamide

生成物 1

HCID 20825930Formyl(2-oxobutyl)formamide

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

A mixture of bromobutan-2-one (10 g, 66 mmol), and sodium diformylamide (6.8 g, 72 mmol) in acetonitrile (50 mL) was stirred at room temperature for 3 hours, then warmed to 35° C. for 2 hours. The mixture was stirred for a further 48 hours at room temperature, then filtered, washing through with additional acetonitrile (50 mL). The filtrate was evaporated under reduced pressure to afford the title compound as a clear oil, 9.1 g.

後処理

  1. temperaturewarmed to 35° C. for 2 hours
  2. stirringThe mixture was stirred for a further 48 hours at room temperature
  3. filtrationfiltered
  4. washwashing through with additional acetonitrile (50 mL)
  5. customThe filtrate was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-94d1bfeda9b647bb942d34ad6ffce6df
出典データセット
uspto-grants-2005_08
特許番号
US06936619B2

反応ノート

読み込み中…